First I have to say how much I love the way James Scott Bell talks about writing and that I highly recommend his books. He explains things in a way that click with me.
One of the things he like to talk about is the death struggle. This is the conflict that locks the protagonist and the antagonist together for the length of the story. Now literary/character driven writers need not call foul. This struggle isn't always a physical death. It can also be psychological (think Holden Caufield or any romance novel) or professional (think police/lawyer stories, even mother trying to help/rescue her child). And yes a story can be more than one, which brings me to my point.
I'll let Mr. Bell explain the rest to you himself if you check out his books. I just want to introduce the concepts so I can brag about how my book is going to be ALL THREE!
Physical Death
Circumstances make the antagonist thin my MC is dangerous to him, so he tries to get rid of danger by killing the MC.
Psychological Death
MC has someone in his life that he doesn't want to disappoint, in part because he feels he owes this person a debt and in part b/c he is desperately seeking this person's approval so he can feel like he belongs. If my MC can't figure the problems of the book out to help this person, he will die a little inside.
Professional Death
This one is a bit of a stretch and might be more applicable in future books with this MC. Ties into the psychological death above. He can view his relationship with the person he doesn't want to disappoint as like a job with duties and responsibilities he can't ignore. If he does ignore them he'll have failed (died) at his "profession."
So my book should be super exciting and emotionally moving, as well as complex, right? We will see.